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Analysis of institutional authors

Font, ACorresponding AuthorGonzalez, AAuthorEtxaniz, OAuthorPardo, JcAuthorNotario, LAuthorEsteve, AAuthor

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January 11, 2024
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Nomogram based on baseline clinicopathological characteristics for predicting bladder cancer-specific survival to neoadjuvant chemotherapy in muscle-invasive bladder cancer

Publicated to: World Journal Of Urology. 40 (11): 2627-2634 - 2022-11-01 40(11), DOI: 10.1007/s00345-022-04147-4

Authors: Font, A; Domenech, M; Buisan, O; Lopez, H; González, A; Etxaniz, O; Matas, M; Elias, X; Gomez, M; Figols, M; Horneros, J; Pardo, JC; Notario, L; de Porras, VR; Perez, I; Areal, J; Esteve, A

Affiliations

Germans Trias & Pujol Res Inst, Badalona Appl Res Grp Oncol B ARGO, Inst Catala Oncol, Barcelona, Spain - Author
Hosp Badalona Germans Trias & Pujol, Med Oncol Dept, Inst Catala Oncol, Barcelona 08972, Spain - Author
Hosp Badalona Germans Trias & Pujol, Pathol Dept, Barcelona, Spain - Author
Hosp Badalona Germans Trias & Pujol, Radiol Dept, Barcelona, Spain - Author
Hosp Badalona Germans Trias & Pujol, Urol Dept, Barcelona, Spain - Author
Xarxa Assistencial Univ Manresa, Med Oncol Dept, Barcelona, Spain - Author
Xarxa Assistencial Univ Manresa, Urol Dept, Barcelona, Spain - Author
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Abstract

Purpose To develop a risk score based on a prognostic model and a nomogram integrating baseline clinicopathological variables to predict bladder cancer-specific survival (BCSS) to neoadjuvant chemotherapy (NAC) in muscle-invasive bladder cancer (MIBC) patients. Methods We retrospectively identified a consecutive sample of 247 MIBC patients treated with cisplatin-based NAC-plus-cystectomy in two Spanish hospitals between 2000 and 2019. Age at MIBC diagnosis, sex, histology, lymphovascular invasion, previous non-MIBC, hydronephrosis, and clinical TNM were included in the initial Cox regression model. A risk score was computed based on the final prognostic model and a nomogram was used to estimate BCSS at 2 and 5 years. Results Median age was 66 years; 89% were males; 83% had pure urothelial carcinoma; 16.2% had previous non-MIBC. Clinical stage was T2N0, T3-4aN0, and Tx-4N + in 24%, 57%, and 19% of patients, respectively. Complete pathological response was seen in 29.4% and downstaging to non-MIBC (ypT1, ypTa, ypTis) in 12.5% of patients. Overall 5-year BCSS was 59%. Four prognostic factors were identified: variant histology, previous non-MIBC, female sex and hydronephrosis. By adding the points attributed to each of these factors, we categorized patients in three groups: low-risk (0 points); intermediate-risk (1-9 points); high-risk (>= 10 points). Five-year BCSS was 72%, 53%, and 15%, respectively (p < 0.0001). Conclusion We developed a nomogram and risk score based on four baseline clinicopathological characteristics to predict BCSS to NAC-plus-cystectomy in MIBC patients. If validated in prospective studies, this nomogram can be useful for selecting patients likely to benefit from NAC.

Keywords

AgedBladder cancer-specific survivalBladder tumorCarcinoma, transitional cellCisplatinCystectomyFemaleGemcitabineHumanHumansHydronephrosisMaleMuscleMuscle-invasive bladder cancerMusclesNeoadjuvant chemotherapyNeoadjuvant therapyNeoplasm invasivenessNomogramNomogramsOutcomesPathologyPrognostic risk scoreProspective studiesProspective studyRetrospective studiesRetrospective studyTherapyTransitional cell carcinomaTumor invasionUrinary bladder neoplasms

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal World Journal Of Urology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Urology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-13:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 8.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 8 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Font Pous, Albert) and Last Author (Esteve Gomez, Ana Maria).

the author responsible for correspondence tasks has been Font Pous, Albert.