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Consejo Nacional de Ciencia y Tecnologia, Grant/Award Number: ID 693636; Instituto de Salud Carlos III, Grant/Award Numbers: CD20/ 00071, CPII20/00009, FI19/00185, PI18/ 00191

Analysis of institutional authors

Gil-Lespinard, MAuthorAlmanza-Aguilera, EAuthorZamora-Ros, RCorresponding Author

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January 11, 2024
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Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study

Publicated to:Obesity. 31 (4): 1146-1158 - 2023-04-01 31(4), DOI: 10.1002/oby.23689

Authors: Castañeda, J; Gil-Lespinard, M; Almanza-Aguilera, E; Llaha, F; Gómez, JH; Bondonno, N; Tjonneland, A; Overvad, K; Katzke, V; Schulze, MB; Masala, G; Agnoli, C; de Magistris, MS; Tumino, R; Sacerdote, C; Skeie, G; Brustad, M; Lasheras, C; Molina-Montes, E; Chirlaque, MD; Barricarte, A; Sonestedt, E; da Silva, M; Johansson, I; Hultdin, J; May, AM; Forouhi, NG; Heath, AK; Freisling, H; Weiderpass, E; Scalbert, A; Zamora-Ros, R

Affiliations

Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark - Author
Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr & Canc, Lhospitalet De Llobregat, Spain - Author
Biosanit Res Inst Granada Ibs GRANADA, Granada, Spain - Author
CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain - Author
Citta Salute & Sci Univ Hosp, Unit Canc Epidemiol, Turin, Italy - Author
Danish Canc Soc, Unit Diet Genes & Environm, Res Ctr, Copenhagen, Denmark - Author
Edith Cowan Univ, Sch Med & Hlth Sci, Inst Nutr Res, Perth, WA, Australia - Author
German Canc Res Ctr, Dept Canc Epidemiol, Heidelberg, Germany - Author
German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany - Author
Hyblean Assoc Epidemiol Res AIRE ONLUS, Ragusa, Italy - Author
IMIB Arrixaca, Dept Epidemiol, Reg Hlth Council, Murcia, Spain - Author
Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England - Author
Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy - Author
Int Agcy Res Canc Nutr IARC WHO, Lyon, France - Author
IRCCS Natl Canc Inst Fdn, Dept Res, Epidemiol & Prevent Unit, Milan, Italy - Author
Lund Univ, Dept Clin Sci Lund, Register Based Epidemiol, Lund, Sweden - Author
Lund Univ, Dept Clin Sci Malmo, Nutr Epidemiol, Malmo, Sweden - Author
Navarra Inst Hlth Res IdiSNA, Pamplona, Spain - Author
Navarra Publ Hlth Inst, Pamplona, Spain - Author
Publ Dent Hlth Serv Competence Ctr Northern Norwa, Tromso, Norway - Author
Umea Univ, Dept Med Biosci, Umea, Sweden - Author
Umea Univ, Dept Odontol, Umea, Sweden - Author
Univ Barcelona, Fac Pharm & Food Sci, Inst Res Nutr & Food Safety INSA, Dept Nutr Food Sci & Gastron,Food Innovat Network, Barcelona, Spain - Author
Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge Biomed Campus,Sch Clin Med, Cambridge, England - Author
Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Sect Environm Hlth, Copenhagen, Denmark - Author
Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol INYTA Jose Mataix, Granada, Spain - Author
Univ Granada, Dept Nutr & Food Sci, Campus Cartuja, Granada, Spain - Author
Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy - Author
Univ Oviedo, Dept Funct Biol, Oviedo, Spain - Author
Univ Potsdam, Inst Nutr Sci, Potsdam, Germany - Author
Univ Tromso, Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway - Author
Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands - Author
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Abstract

Objective: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5years. Methods: A total of 349,165 men and women aged 25 to 70years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from nine European countries. Body weight was measured at baseline and at follow-up after a median time of 5years. Polyphenol intake, including four main polyphenol classes and eighteen subclasses, was estimated using validated dietary questionnaires and Phenol-Explorer. Multilevel mixed linear regression models were used to estimate the associations. Results: Participants gained, on average, 2.6 kg (5.0 kg) over 5years. Total flavonoids intake was inversely associated with body weight change (-0.195kg/5 years, 95% CI: -0.262 to -0.128). However, the intake of total polyphenols (0.205kg/5 years, 95% CI: 0.138 to 0.272) and intake of hydroxycinnamic acids (0.324kg/5 years, 95% CI: 0.267 to 0.381) were positively associated with body weight gain. In analyses stratified by coffee consumption, hydroxycinnamic acid intake was positively associated with body weight gain in coffee consumers (0.379kg/5 years, 95% CI: 0.319 to 0.440), but not in coffee nonconsumers (-0.179kg/5 years, 95% CI: -0.490 to 0.133). Conclusions: Higher intakes of flavonoids and their subclasses are inversely associated with a modest body weight change. Results regarding hydroxycinnamic acids in coffee consumers require further investigation.

Keywords

AdultAgedAlcohol consumptionAlkymethoxyphenolAnthocyaninAnthropometryArticleBmiBody weightBody weight gainChalcone derivativeClimacteriumCoffeeCoffee consumptionCohort analysisCoumaric acidCoumaric acidsDietDihydrochalconeEating out of homeEducational statusEnergy expenditureEuropean countriesFatty acid oxidationFemaleFlavan 3 olFlavanoneFlavonoidFlavonoidsFollow upFood frequency questionnaireGeographic distributionHumanHumansInterviewIsoflavonoidLifestyle modificationLignanMajor clinical studyMaleMalignant neoplasmManagementMenstrual cycleMetabolismNeoplasmNeoplasmsNutritionObesityOverweightPatternsPhysical activityPolyphenolPolyphenolsPopulationPostmenopauseProanthocyanidinProspective studiesProspective studyQuestionnaireSmoking cessationStilbeneTheaflavinThermogenesisTyrosolUnclassified drugUnderweightWeight gainWomen

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Obesity due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 40/186, thus managing to position itself as a Q1 (Primer Cuartil), in the category Endocrinology & Metabolism.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.33, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 1
  • Scopus: 2

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 25.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 33 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 11.5.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).
  • The number of mentions in news outlets: 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Australia; Denmark; France; Germany; Italy; Netherlands; Norway; Sweden; United Kingdom; United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Castañeda, J) and Last Author (ZAMORA ROS, RAUL).

the author responsible for correspondence tasks has been ZAMORA ROS, RAUL.