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Impact on the Sustainable Development Goals (SDGs)

Analysis of institutional authors

Mena MCorresponding AuthorTous SCorresponding AuthorAlemany, LCorresponding AuthorTaberna MCorresponding Author

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February 18, 2019
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Article

Human papillomavirus in premalignant oral lesions: No evidence of association in a Spanish cohort.

Publicated to:Plos One. 14 (1): e0210070-e0210070 - 2019-01-16 14(1), DOI: 10.1371/journal.pone.0210070

Authors: Gomez-Armayones, S; Chimenos-Küstner, E; Marí, A; Tous, S; Penin, R; Clavero, O; Quirós, B; Pavon, MA; Taberna, M; Alemany, L; Servitje, O; Mena, M

Affiliations

Bellvitge Univ Hosp, Dept Dermatol, Barcelona, Spain - Author
Bellvitge Univ Hosp, Dept Med, Barcelona, Spain - Author
Bellvitge Univ Hosp, Dept Oral & Maxillofacial Surg, Barcelona, Spain - Author
Bellvitge Univ Hosp, Dept Pathol, Barcelona, Spain - Author
Cancer. Cancer Epigenetics and Biology Program. Ageing and Cancer - Author
Cancer. Epidemiology, Public Health, Cancer Prevention and Palliative Care Program. Infections and Cancer - Author
Cancer. Molecular Mechanisms and Experimental Therapy in Oncology Program. Head and neck diseases - Author
Cancer. Molecular Mechanisms and Experimental Therapy in Oncology Program. Hematopoyetic and lymphoid tumors - Author
Catalan Inst Oncol ICO, Canc Epidemiol Res Program, IDIBELL, Barcelona, Spain - Author
Catalan Inst Oncol ICO, Dept Med Oncol, ONCOBELL, IDIBELL, Barcelona, Spain - Author
CIBER Primary & Secondary Prevent Viral Induced C, Madrid, Spain - Author
Inst Salud Carlos III, CIBERESP, Epidemiol & Publ Hlth, Madrid, Spain - Author
Odontol Univ Hosp Barcelona, Dept Odontostomatol, Barcelona, Spain - Author
Traslational Medicine. Digestive system, diagnostics, pharmacogenetics, care support and clinical prevention Program. Oral Health and Masticatory System - Author
Univ Barcelona, Barcelona, Spain - Author
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Abstract

Human papillomavirus (HPV) is the cause of a fraction of head and neck squamous cell carcinoma. Although this relation is well-known, it is still not clear the role of HPV in premalignant oral lesions such as oral lichen planus (OLP) and dysplasia. We aimed to evaluate the HPV-DNA prevalence and type distribution in a set of oral biopsies obtained from patients diagnosed with OLP and dysplasia, as well as the role of HPV in these lesions.A retrospective cohort of all premalignant oral lesions consecutively diagnosed from March 30th 1995 to May 21st 2014 at Hospital of Bellvitge and Odontological University Hospital of Bellvitge was identified and classified in four groups: OLP (groups 1 and 2) and dysplasias (groups 3 and 4) that progressed or not to invasive cancer during follow-up. A random selection targeting 25 cases was aimed to be performed for each group. All selected cases were subjected to pathological evaluation, DNA quality control and HPV-DNA detection. HPV-DNA positive samples were further subject to p16INK4a analysis.A total of 83 cases yielded a valid HPV-DNA result. From those, 7 and 34 cases were OLP that progressed or not to invasive cancer during follow-up, whereas 24 and 18 cases were displasias that progressed or not to invasive cancer during follow-up, respectively. HPV-DNA was detected in 4 samples (3 dysplastic lesions and 1 OLP). Two samples were HPV16 positive (2%), 1 sample HPV18 positive (1%) and 1 sample (1%) was HPV indeterminate. Two out of four HPV-DNA positive cases had high p16INK4a expression and none of the HPV positive cases progressed to invasive cancer during long-term follow-up.We found a low HPV-DNA attributable fraction in premalignant lesions of the oral cavity, suggesting that HPV is unlikely to play a significant role in oral carcinogenesis in our setting.

Keywords

Good health and well-being

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plos One due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2019, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Multidisciplinary. Notably, the journal is positioned above the 90th percentile.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 4.86, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-02, the following number of citations:

  • WoS: 22
  • Scopus: 23
  • Europe PMC: 13
  • Open Alex: 25

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-02:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 60.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 74 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.35.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Continuing with the social impact of the work, it is important to emphasize that, due to its content, it can be assigned to the area of interest of ODS 3 - Good Health and Well-Being, with a probability of 75% according to the mBERT algorithm developed by Aurora University.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (Taberna Sanz, Miren).

the authors responsible for correspondence tasks have been MENA CERVIGNON, MARISA, Clavero, O, Tous Belmonte, Sara, Penín R, Clavero O, Quiros B, Alemany Vilches, Maria Eulalia and Taberna Sanz, Miren.